Yeah, quite easy, you can take a taxi or a bus. It's about 125Km over good roads until Sisaphon then the road becomes crappier (although work was ongoing last time I went through, it may be sealed completely now). I can't tell you how long it takes in a bus as I have only cycled it.
I did that trip in January this year. My hotel in Battambang arranged a shared taxi for $7 or $9 depending on rear or front seat. The taxi dropped me at the border, you clear customs, get a tuk-tuk on the other side and it will take you to the bus station. I took the bus to the Mo Chit station. The taxi ride was only a couple hours and the road was in better shape than in the past.