From Ko Chang you'll need to travel via Bangkok to get to Thailand's southern islands.
If you mean between Siem Reap and Ko Chang , Chanthaburi is an interesting enough place for an overnight stay. Otherwise, heading further south there's stacks to see and do -- really depends on your interests...
If you're wondering how to get from SR to KC, give this story a read.
Hope that helps
#2 somtam2000 has been a member since 21/1/2004. Location: Indonesia. Posts: 7,652
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